丁昌华

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丁昌华个人简介

 

姓名:丁昌华

出生日期:1977年12月

办公室:E510

职称:副研究员

学历:博士研究生

Email:dingchanghua@shu.edu.cn

【个人简介】

2000年本科毕业于江西师范大学,2005年在中国科学院上海有机化学研究所获得博士学位 (导师:侯雪龙 研究员)2005年至2009年先后在日本冈山理科大学 (导师:Junzo Otera教授)和京都大学 (导师:Keiji   Maruoka教授)从事博士后研究。2009年至2018年在中国科学院上海有机化学研究所金属有机化学国家重点实验室工作 (副研究员)20186月入职上海大学化学系 (副研究员)

研究兴趣主要在于发展新的过渡金属催化不对称反应及其在生物活性分子和天然产物合成中的应用。在国内国际学术刊物发表SCI论文50余篇,其中以第一作者或通讯作者在Chem.   Rev.,   Angew. Chem. Int. Ed., ACS Catalysis等期刊(IF>5发表论文18篇;引用次数1300次以上,h指数为21;论文多次被Synfacts等国际评论期刊作为亮点介绍。受邀在Elsevier出版社的丛书撰写章节。主持国家自然科学基金面上项目3项和青年基金项目1项,主持上海市自然科学基金项目1项。2015年获得德国Thieme出版社的Thieme Chemistry Journals Award。担任国家自然科学基金项目通讯评审专家,浙江省自然科学基金项目通讯评审专家。担任ACS   Catalysis, Chemical Communications, Organic Letters等杂志审稿人。

【讲授课程】

《有机化学》、《金属有机化学》、《药物化学》、《有机化学实验》

 

【科研项目】

1.      国家自然科学基金面上基金 (项目编号:22071143)基于π-烯丙基钯1,4/5-两性离子与烯/炔烃的不对称环加成反应研究,项目主持人。

2.      国家自然科学基金面上基金 (项目编号:21772215)钯催化烯基三元环与单吸电子基活化烯烃的不对称[3+2]环加成反应及应用研究,项目主持人。

3.      国家自然科学基金面上基金 (项目编号:21372242)通过钯催化不对称Heck反应实现的动力学拆分及应用研究,项目主持人。

4.      国家自然科学基金青年基金 (项目编号:21002113)钯催化不对称烯丙基取代反应对亲核试剂的去对称化反应研究及其在天然产物合成中的应用,项目主持人。

5.      上海市科学技术委员会自然科学基金 (项目编号:10ZR1436800)钯催化不对称烯丙基取代反应对于碳亲核试剂的动力学拆分,项目主持人。

6.      国家自然科学基金重点项目 (项目编号:21532010)基于亲核试剂对π-烯丙基过渡金属络合物反应选择性的反应方法学研究,主要骨干。

【代表性论文】

1.           Cun   Yang, Zhi-Xiong Yang, Chang-Hua Ding,* Bin Xu, Xue-Long Hou*

Development of   Dipolarophiles for Catalytic Asymmetric Cycloadditions through Pd-π-allyl   zwitterions

Chem.   Rec.   2021, 21, 1442–1454.

2.           Weixiang   Wang, Tianqi Liu, Chang-Hua Ding,* Bin Xu*,

C(sp3)–H   Functionalization with Isocyanides

Org.   Chem. Front. 2021, 8,   3525-3542.

3.           Juan   Du, Yuan-Da Hua, Yang-Jie Jiang, Shuai Huang, Di Chen, Chang-Hua Ding,*   Xue-Long Hou*

Palladium-Catalyzed   Asymmetric Decarboxylative [4+2] Dipolar Cycloaddition of 4‑Vinyl-1,3-dioxan-2-ones   with α,β-Disubstituted Nitroalkenes Enabled by a Benzylic Substituted P,N-Ligand

Org.   Lett.   2020, 22, 5375−5379.

4.           Wen-Ping   Ding, Gao-Peng Zhang, Yang-Jie Jiang, Juan Du, Xiu-Yan Liu, Di Chen, Chang-Hua   Ding,* Qing-Hai Deng,* Xue-Long Hou*

Electron-Deficient   Alkynes as Dipolarophile in Pd-Catalyzed Enantioselective (3+2) Cycloaddition   Reaction with Vinyl Cyclopropanes

Org.   Lett.   2019, 21, 6805–6810.

5.           Leiyang   Zhao, Bingxin Liu, Qitao Tan, Chang-Hua Ding,* and Bin Xu*

Silver-Assisted   Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β‑Carbonyl   α‑Iminonitriles

Org.   Lett.   2019, 21, 9223−9227.

6.           Fei-Le   Yu, Da-Chang Bai, Xiu-Yan Liu, Yang-Jie Jiang, Chang-Hua Ding,* Xue-Long   Hou*

Pd-Catalyzed   Allylic Alkylation of gem-Alkyl,Aryl-Disubstituted Allyl Reagents with   Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary   Carbon Centers

     ACS Catalysis, 2018, 8, 3317−3321.

7.           Jian-Qiang   Huang, Wei Liu, Bao Hui Zheng, Xiu Yan Liu, Zhen Yang, Chang-Hua Ding,*   Hao Li, Qian Peng,* Xue-Long Hou*

Pd-Catalyzed Asymmetric Cyclopropanation   Reaction of Acyclic Amides with Allyl and Polyenyl Carbonates. Experimental   and Computational Studies for the Origin of Cyclopropane Formation

ACS Catalysis, 2018,   8, 1964-1972.(封面论文).

8.           Wan-Ying   Wang, Jing-Yu Wu, Qing-Rong Liu, Xiu-Yan Liu, Chang-Hua Ding,*   Xue-Long Hou*

Palladium/N‑Heterocyclic   Carbene (NHC)-Catalyzed Asymmetric [3+2] Cycloaddition Reaction of Vinyl   Epoxides with Allenic Amides

Org.   Lett.   2018, 20, 4773−4776. (Highlighted by Synfacts, 2018, 14,   1163).

9.           Juan   Du, Yang-Jie Jiang, Jia-Jia Suo, Wen-Qiong Wu, Xiu-Yan Liu, Di Chen, Chang-Hua   Ding,* Yin Wei,* Xue-Long Hou*

Trisubstituted   alkenes with a single activator as dipolarophiles in a highly diastereo- and   enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis

Chem.   Commun., 2018, 54, 13143–13146.

10.     Jia-Jia   Suo, Juan Du, Qing-Rong Liu, Di Chen, Chang-Hua Ding,* Qian Peng,*   Xue-Long Hou*

Highly   Diastereo- and Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of   Vinyl Epoxides and α,β-Unsaturated Ketones

Org.   Lett.   2017, 19, 6658−6661. (Highlighted by Synfacts, 2018, 14,   166).

11.     Yang-Jie   Jiang, Gao-Peng Zhang, Jian-Qiang Huang, Di Chen, Chang-Hua Ding,*   Xue-Long Hou*

Palladium-Catalyzed Asymmetric Allylic   Alkylation of Alkyl-Substituted Allyl Reagents with Acyclic Amides

Org. Lett. 2017, 19,   5932–5935. (Highlighted by Synfacts, 2018,   14, 45).

12.     Chao-Fan Xu, Bao-Hui Zheng, Jia-Jia Suo, Chang-Hua Ding,*   Xue-Long Hou*  

Highly Diastereo- and   Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Aziridines   and α, β-Unsaturated Ketones

Angew.   Chem. Int. Ed. 2015, 54, 1604-1607. (Highlighted by Org. Chem. Portal网站;《有机化学》杂志亮点介绍).

13.     Qing-Song Zhang, Shi-Li Wan, Di Chen, Chang-Hua Ding,*   Xue-Long Hou*

Palladium-catalyzed   asymmetric intermolecular Mizoroki–Heck reaction for construction of a chiral   quaternary carbon center

Chem.   Commun. 2015, 51,   12235-12238. (Highlighted by Org. Chem. Portal网站).

14.     Bai-Lin Lei, Qing-Song Zhang, Wei-Hua Yu, Qiu-Ping Ding, Chang-Hua   Ding,* Xue-Long Hou*

Kinetic Resolution of   2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric   Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine   (-)-209I

Org. Lett. 2014, 16, 1944-1947.

15.     Guang-Cun Ge, Xiao-Jun Huang, Chang-Hua Ding,* Shi-Li   Wan, Li-Xin Dai, Xue-Long Hou*

A new strategy to construct   a C=C-CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines:   an efficient synthesis of trifluoromethyl containing building blocks   4-trifluoromethyl-2,3-dihydro-pyrroliums

Chem. Commun, 2014, 50, 3048-3051.

16.     Xiao-Fei   Yang, Xiao-Hui Li, Chang-Hua Ding,* Chao-Fan Xu, Li-Xin Dai, Xue-Long   Hou*

Pd-catalyzed allylic alkylation of   dienyl carbonates with nitromethane with high C-5 regioselectivity

Chem. Commun. 2014,   50, 484-486.

17.     Yang Yu, Xiao-Fei Yang, Chao-Fan Xu, Chang-Hua Ding,*   Xue-Long Hou* Desymmetrization of Bicyclo[3.n.1]-3-one Derivatives by   Palladium-Catalyzed Asymmetric Allylic Alkylation

Org. Lett. 2013, 15, 3880-3883. ( Highlighted by Synfacts, 2013, 9,   1195).

18.     Chang-Hua Ding,* Xue-Long Hou*

Catalytic Asymmetric   Propargylation

Chem. Rev. 2011, 111, 1914-1937.

专著章节:

1.       Zhi-Chun Zheng, Cun Yang, Xin Kuang, Chang-Hua Ding

Thiophenes and Their   Benzo Derivatives: Synthesis

In “Comprehensive   Heterocyclic Chemistry IV

DOI: 10.1016/B978-0-12-409547-2.14932-7

2.       Chang-Hua Ding, Xue-Long Hou

Nucleophiles   with Allyl Metal Complexes

In   “Additions to and Substitutions at C‐C π‐Bonds

Comprehensive   Organic Synthesis 2nd edition, Vol. 4. pp 648-698 (Vol. Eds: S. Ma   and J. Zhang), Elsevier, 2014

3.       Chang-Hua Ding, Xue-Long Hou*

Transition Metal-Catalyzed Asymmetric   Allylation

Top Organomet Chem 2011, 36,   247-286.

 

 

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