【个人简介】 2000年本科毕业于江西师范大学，2005年在中国科学院上海有机化学研究所获得博士学位 (导师：侯雪龙 研究员)。2005年至2009年先后在日本冈山理科大学 (导师：Junzo Otera教授)和京都大学 (导师：Keiji Maruoka教授)从事博士后研究。2009年至2018年在中国科学院上海有机化学研究所金属有机化学国家重点实验室工作 (副研究员)。2018年6月入职上海大学化学系 (副研究员)。 研究兴趣主要在于发展新的过渡金属催化不对称反应及其在生物活性分子和天然产物合成中的应用。在国内国际学术刊物发表SCI论文50余篇，其中以第一作者或通讯作者在Chem. Rev., Angew. Chem. Int. Ed., ACS Catalysis等期刊（IF>5）发表论文18篇；引用次数1300次以上，h指数为21；论文多次被Synfacts等国际评论期刊作为亮点介绍。受邀在Elsevier出版社的丛书撰写章节。主持国家自然科学基金面上项目3项和青年基金项目1项，主持上海市自然科学基金项目1项。2015年获得德国Thieme出版社的Thieme Chemistry Journals Award。担任国家自然科学基金项目通讯评审专家，浙江省自然科学基金项目通讯评审专家。担任ACS Catalysis, Chemical Communications, Organic Letters等杂志审稿人。 【讲授课程】 《有机化学》、《金属有机化学》、《药物化学》、《有机化学实验》 【科研项目】 1． 国家自然科学基金面上基金 (项目编号：22071143)，“基于π-烯丙基钯1,4/5-两性离子与烯/炔烃的不对称环加成反应研究”，项目主持人。 2． 国家自然科学基金面上基金 (项目编号：21772215)，“钯催化烯基三元环与单吸电子基活化烯烃的不对称[3+2]环加成反应及应用研究”，项目主持人。 3． 国家自然科学基金面上基金 (项目编号：21372242)，“通过钯催化不对称Heck反应实现的动力学拆分及应用研究”，项目主持人。 4． 国家自然科学基金青年基金 (项目编号：21002113)，“钯催化不对称烯丙基取代反应对亲核试剂的去对称化反应研究及其在天然产物合成中的应用”，项目主持人。 5． 上海市科学技术委员会自然科学基金 (项目编号：10ZR1436800)，“钯催化不对称烯丙基取代反应对于碳亲核试剂的动力学拆分”，项目主持人。 6． 国家自然科学基金重点项目 (项目编号：21532010)，“基于亲核试剂对π-烯丙基过渡金属络合物反应选择性的反应方法学研究”，主要骨干。 【代表性论文】 1. Cun Yang, Zhi-Xiong Yang, Chang-Hua Ding,* Bin Xu, Xue-Long Hou* Development of Dipolarophiles for Catalytic Asymmetric Cycloadditions through Pd-π-allyl zwitterions Chem. Rec. 2021, 21, 1442–1454. 2. Weixiang Wang, Tianqi Liu, Chang-Hua Ding,* Bin Xu*, C(sp3)–H Functionalization with Isocyanides Org. Chem. Front. 2021, 8, 3525-3542. 3. Juan Du, Yuan-Da Hua, Yang-Jie Jiang, Shuai Huang, Di Chen, Chang-Hua Ding,* Xue-Long Hou* Palladium-Catalyzed Asymmetric Decarboxylative [4+2] Dipolar Cycloaddition of 4‑Vinyl-1,3-dioxan-2-ones with α,β-Disubstituted Nitroalkenes Enabled by a Benzylic Substituted P,N-Ligand Org. Lett. 2020, 22, 5375−5379. 4. Wen-Ping Ding, Gao-Peng Zhang, Yang-Jie Jiang, Juan Du, Xiu-Yan Liu, Di Chen, Chang-Hua Ding,* Qing-Hai Deng,* Xue-Long Hou* Electron-Deficient Alkynes as Dipolarophile in Pd-Catalyzed Enantioselective (3+2) Cycloaddition Reaction with Vinyl Cyclopropanes Org. Lett. 2019, 21, 6805–6810. 5. Leiyang Zhao, Bingxin Liu, Qitao Tan, Chang-Hua Ding,* and Bin Xu* Silver-Assisted Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β‑Carbonyl α‑Iminonitriles Org. Lett. 2019, 21, 9223−9227. 6. Fei-Le Yu, Da-Chang Bai, Xiu-Yan Liu, Yang-Jie Jiang, Chang-Hua Ding,* Xue-Long Hou* Pd-Catalyzed Allylic Alkylation of gem-Alkyl,Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers ACS Catalysis, 2018, 8, 3317−3321. 7. Jian-Qiang Huang, Wei Liu, Bao Hui Zheng, Xiu Yan Liu, Zhen Yang, Chang-Hua Ding,* Hao Li, Qian Peng,* Xue-Long Hou* Pd-Catalyzed Asymmetric Cyclopropanation Reaction of Acyclic Amides with Allyl and Polyenyl Carbonates. Experimental and Computational Studies for the Origin of Cyclopropane Formation ACS Catalysis, 2018, 8, 1964-1972.（封面论文）. 8. Wan-Ying Wang, Jing-Yu Wu, Qing-Rong Liu, Xiu-Yan Liu, Chang-Hua Ding,* Xue-Long Hou* Palladium/N‑Heterocyclic Carbene (NHC)-Catalyzed Asymmetric [3+2] Cycloaddition Reaction of Vinyl Epoxides with Allenic Amides Org. Lett. 2018, 20, 4773−4776. (Highlighted by Synfacts, 2018, 14, 1163). 9. Juan Du, Yang-Jie Jiang, Jia-Jia Suo, Wen-Qiong Wu, Xiu-Yan Liu, Di Chen, Chang-Hua Ding,* Yin Wei,* Xue-Long Hou* Trisubstituted alkenes with a single activator as dipolarophiles in a highly diastereo- and enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis Chem. Commun., 2018, 54, 13143–13146. 10. Jia-Jia Suo, Juan Du, Qing-Rong Liu, Di Chen, Chang-Hua Ding,* Qian Peng,* Xue-Long Hou* Highly Diastereo- and Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Epoxides and α,β-Unsaturated Ketones Org. Lett. 2017, 19, 6658−6661. (Highlighted by Synfacts, 2018, 14, 166). 11. Yang-Jie Jiang, Gao-Peng Zhang, Jian-Qiang Huang, Di Chen, Chang-Hua Ding,* Xue-Long Hou* Palladium-Catalyzed Asymmetric Allylic Alkylation of Alkyl-Substituted Allyl Reagents with Acyclic Amides Org. Lett. 2017, 19, 5932–5935. (Highlighted by Synfacts, 2018, 14, 45). 12. Chao-Fan Xu, Bao-Hui Zheng, Jia-Jia Suo, Chang-Hua Ding,* Xue-Long Hou* Highly Diastereo- and Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Aziridines and α, β-Unsaturated Ketones Angew. Chem. Int. Ed. 2015, 54, 1604-1607. (Highlighted by Org. Chem. Portal网站;《有机化学》杂志“亮点介绍”). 13. Qing-Song Zhang, Shi-Li Wan, Di Chen, Chang-Hua Ding,* Xue-Long Hou* Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for construction of a chiral quaternary carbon center Chem. Commun. 2015, 51, 12235-12238. (Highlighted by Org. Chem. Portal网站). 14. Bai-Lin Lei, Qing-Song Zhang, Wei-Hua Yu, Qiu-Ping Ding, Chang-Hua Ding,* Xue-Long Hou* Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I Org. Lett. 2014, 16, 1944-1947. 15. Guang-Cun Ge, Xiao-Jun Huang, Chang-Hua Ding,* Shi-Li Wan, Li-Xin Dai, Xue-Long Hou* A new strategy to construct a C=C-CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums Chem. Commun, 2014, 50, 3048-3051. 16. Xiao-Fei Yang, Xiao-Hui Li, Chang-Hua Ding,* Chao-Fan Xu, Li-Xin Dai, Xue-Long Hou* Pd-catalyzed allylic alkylation of dienyl carbonates with nitromethane with high C-5 regioselectivity Chem. Commun. 2014, 50, 484-486. 17. Yang Yu, Xiao-Fei Yang, Chao-Fan Xu, Chang-Hua Ding,* Xue-Long Hou* Desymmetrization of Bicyclo[3.n.1]-3-one Derivatives by Palladium-Catalyzed Asymmetric Allylic Alkylation Org. Lett. 2013, 15, 3880-3883. ( Highlighted by Synfacts, 2013, 9, 1195). 18. Chang-Hua Ding,* Xue-Long Hou* Catalytic Asymmetric Propargylation Chem. Rev. 2011, 111, 1914-1937. 专著章节： 1. Zhi-Chun Zheng, Cun Yang, Xin Kuang, Chang-Hua Ding Thiophenes and Their Benzo Derivatives: Synthesis In “Comprehensive Heterocyclic Chemistry IV” DOI: 10.1016/B978-0-12-409547-2.14932-7 2. Chang-Hua Ding, Xue-Long Hou Nucleophiles with Allyl Metal Complexes In “Additions to and Substitutions at C‐C π‐Bonds” Comprehensive Organic Synthesis 2nd edition, Vol. 4. pp 648-698 (Vol. Eds: S. Ma and J. Zhang), Elsevier, 2014 3. Chang-Hua Ding, Xue-Long Hou* Transition Metal-Catalyzed Asymmetric Allylation Top Organomet Chem 2011, 36, 247-286. |