今日化学系列报告 第13讲: Chemical regulation of Jasmonic acid biosynthesis
创建时间：  2009/10/26  李敏杰   浏览次数：   返回


    题目： Chemical regulation of Jasmonic acid biosynthesis
    报告人： Prof. Jingming Wang (Department of Biotechnology, Akita prefectural University, Japan)
    时间： 2009.11.4 （星期三）下午14:00
    地点： 化学楼HA101
    主办部门： 化学系
    报告人简介： Jasmonic acid and methyl jasmonate, collectively called jasmonates (JAs), are important signal molecules that regulate gene expression in plant development and defense responses to herbivore attack and mechanical wounding. Genetic analysis of JAs biosynthesis mutants gave evidences that the allene oxide synthase (AOS) is a major control point in the biosynthetic pathway of JAs. Specific inhibitors of AOS are, therefore, useful for dissecting plant defense signaling pathways, as well as regulation mechanism of plant growth and development. In this presentation, I will describe the development of specific inhibitors targeting on the AOS, a key enzyme that catalyzes the first step in the specific pathway of JAs biosynthesis. The AOS inhibitor was designed on the basis of catalytic cycle of AOS. The inhibitory activity of synthesized compounds was evaluated by using recombinant AOS from Arabidopsis expressed in E. coli. Structure-activity relationship studies revealed a potent AOS inhibitor, JM-8686, with an IC50 approximately 10 nM. Steady-state kinetic analysis on the inhibition mechanism of JM-8686 indicated that it was a competitive inhibitor of AOS. In vivo application studies of this synthetic series are now in progress. Also, I would like give a brief talk about Japan and Akita prefectural University.

上一条：今日化学系列报告 第14讲: Designed laser quantum control of enzyme reactivity

下一条：研究论文快讯 之七

  版权所有 © 上海大学   沪ICP备09014157   沪公网安备31009102000049号  地址：上海市宝山区上大路99号    邮编：200444   电话查询
 技术支持：上海大学信息化工作办公室   联系我们