林锦鸿

创建时间:  2023/03/16  刘志玲   浏览次数:   返回

  林锦鸿

副教授、博士生导师

出生日期:1983-02

办公室:E510

学历:博士

通信地址:上海市宝山区上大路99号

Email:jlin@shu.edu.cn

【个人简历】

2001/9-2005/7: 东华大学,学士

2005/9-2011/1:中科院上海有机化学研究所,博士,导师:肖吉昌研究员

2011/3-2013/2:纽约州立大学Albany分校,博士后,导师:John T. Welch

2013/3-2021/4:中科院上海有机化学研究所,副研究员

2021/4-至今:  上海大学化学系,副教授

【研究方向】

有机氟化学、过渡金属催化

【人才项目】

2019年入选中科院青年创新促进会

【科研项目】

(1)国家自然科学基金面上项目,2023年1月至2026年12月,主持

(2)上海市科学技术委员会自然科学基金,面上项目,2022年04月至 2025年 03月,主持

(3) 国家自然科学基金青年科学基金项目,2016年01月至 2018年 12月,主持

(4) 上海市科学技术委员会自然科学基金项目,2014年07月至2017年06月,主持

【论文著作】第一作者或通讯作者文章(按时间倒序排列)

(1) Chen, L.-Y.; Pan, P.-F.; Lin, J.-H.;* Jin, C. M.;* Xiao, J.-C.* Tf2O as a CF3 source for the Synthesis of Trifluoromethoxylation Reagent nC4F9SO3CF3, J. Org. Chem., 2023, accepted.

(2) Luo, L.; Lin, J.-H.;* Xiao, J.-C.,* Dehydroxylative Cyanation of Alcohols Promoted by Ph3P/ICH2CH2I, Synlett, 2023, accepted.

(3) Zhu, Y.-R.; Lin, J.-H.;* Xiao, J.-C.* Triphenylphosphine/1,2-Diiodoethane-Promoted Formylation of Indoles with N,N-Dimethylformamide. Synlett 2022, 33, 259-263.

(4) Zhang, F.-X.; Lin, J.-H.;* Xiao, J.-C.* Difluoromethylsulfonyl Imidazolium Salt for Difluoromethylation of Alkenes. Org Lett 2022, 24, 7611-7616.

(5) Yang, X.-J.; Lin, J.-H.;* Xiao, J.-C.* Trifluoromethylsulfonyl pyridinium salt for trifluoromethythiolation of indoles. J. Fluorine Chem. 2022, 263, 110047.

(6) Qian, B. Y.; Zhang, W.; Lin, J.-H.;* Cao, W.;* Xiao, J.-C.* anti-Markovnikov Iodofluorination of Alkenes. Chem Asian J. 2022, 17, e202200184.

(7) Hu, Y.; Wang, X.; Ren, N.; Li, N.; Li, J.; Chen, J.; Zhang, H.; Deng, H.; Cao, W.;* Lin, J.-H.* A Convenient Synthesis of Fluoroalkylated Benzimidazole- or Indole-fused Benzoxazines. Eur. J. Org. Chem. 2022, 2022, e202101501.

(8) Zhou, W.; Pan, W.-J.; Chen, J.; Zhang, M.; Lin, J.-H.;* Cao, W.;* Xiao, J.-C.* Transition-metal difluorocarbene complexes. Chem. Commun. 2021, 57, 9316-9329.

(9) Yang, Y.-F.; Lin, J.-H.;* Xiao, J.-C.* Starting from Styrene: A Unified Protocol for Hydrotrifluoromethylation of Diversified Alkenes. Org. Lett. 2021, 23, 9277-9282.

(10) Wu, W.-F.; Lin, J.-H.;* Xiao, J.-C.;* Cao, Y.-C.; Ma, Y. Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes. Asian J. Org. Chem. 2021, 10, 485-495.

(11) Wang, X.; Sun, X.; Li, N.; Chen, J.; Zhang, H.; Deng, H.; Lin, J.-H.;* Cao, W.* The synthesis of perfluoroalkylated indolizines via tandem cyclization/aromatization. J. Fluorine Chem. 2021, 251, 109900.

(12) Hu, Y.; Ye, L.; Chen, J.; Zhang, H.; Deng, H.; Lin, J.-H.;* Cao, W.* An Efficient Construction of CF3-Substituted Spirooxindole-Fused Benzo[a]quinolizidines by a Three-Component Cyclization. Eur. J. Org. Chem. 2021, 2021, 4405-4408.

(13) Hao, F.; Shang, X.; Liu, Z.; Zhang, H.;* Lin, J.-H.;* Xiao, J.-C.* Rh-catalyzed tunable defluorinative borylation. Chem. Commun. 2021, 57, 7124-7127.

(14) Zhang, W.; Gu, Y. C.; Lin, J.-H.;* Xiao, J.-C.* Dehydroxylative Fluorination of Tertiary Alcohols. Org. Lett. 2020, 22, 6642-6646.

(15) Xu, Z.-W.; Zhang, W.; Lin, J.-H.;* Jin, C. M.;* Xiao, J.-C.* Pd‐catalyzed transfer of difluorocarbene for three component cross‐coupling. Chin. J. Chem. 2020, 38, 1647-1650.

(16) Xiao, X.; Zheng, Z.-T.; Li, T.; Zheng, J.-L.; Tao, T.; Chen, L.-M.; Gu, J.-Y.; Yao, X.; Lin, J.-H.;* Xiao, J.-C.* Recent Advances in Difluoromethylthiolation. Synthesis 2020, 52, 197-207.

(17) Xiao, X.; Yao, X.; Yu, J.; Tang, T.; Xiao, C.; Gu, J.; Lin, J.-H.;* Zheng, X.;* Xiao, J.-C.* A one-step synthesis of gem-difluoroolefins from alcohols. J. Fluorine Chem. 2020, 240.

(18) Lin, J.-H.; Xiao, J.-C.* Fluorinated Ylides/Carbenes and Related Intermediates from Phosphonium/Sulfonium Salts. Acc. Chem. Res. 2020, 53, 1498-1510.

(19) Long, J.; Chen, J.; Li, R.; Liu, Z.; Xiao, X.; Lin, J.-H.;* Zheng, X.;* Xiao, J.-C.* Ph3P/I–-Promoted Dichlorination or Dibromination of Epoxides with XCH2CH2X (X = Cl or Br). Synlett 2019, 30, 181-184.

(20) Liu, Z.; Long, J.; Xiao, X.; Lin, J.-H.;* Zheng, X.;* Xiao, J.-C.;* Cao, Y.-C. Ph3P+CF2CO2- as an F- and :CF2 source for trifluoromethylthiolation of alkyl halides. Chin. Chem. Lett. 2019, 30, 714 - 716.

(21) Zhao, Y.; Lin, J.-H.;* Hang, X.-C.;* Xiao, J.-C.* Ag-Mediated Trifluoromethylthiolation of Inert Csp3–H Bond. J. Org. Chem. 2018, 83, 14120-14125.

(22) Zhang, W.; Lin, J.-H.;* Xiao, J.-C.* Cu-catalyzed chlorotrifluoromethylation of alkenes with CF3SO2Cl. J. Fluorine Chem. 2018, 215, 25-31.

(23) Zhang, W.; Chen, J.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y.-C. Rapid Dehydroxytrifluoromethoxylation of Alcohols. iScience 2018, 5, 110-117.

(24) Pan, X.-Y.; Zhao, Y.; Qu, H.-A.; Lin, J.-H.;* Hang, X.-C.;* Xiao, J.-C.* Tri- and di-fluoroethylation of alkenes by visible light photoredox catalysis. Org. Chem. Front. 2018, 5, 1452-1456.

(25) Zeng, X.-L.; Deng, Z.-Y.; Liu, C.; Zhao, G.; Lin, J.-H.;* Zheng, X.;* Xiao, J.-C.* Nucleophilic monofluoroalkylation with fluorinated phosphonium salt toward carbonyl and imine compounds. J. Fluorine Chem. 2017, 193, 17-23.

(26) Yu, J.; Lin, J.-H.;* Xiao, J.-C.* Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines. Angew. Chem. Int. Ed. 2017, 56, 16669-16673.

(27) Huang, Q.-X.; Zheng, Q.-T.; Duan, Y.; Lin, J.-H.;* Xiao, J.-C.;* Zheng, X.* Diastereoselective Synthesis of CF3-Containing Vicinal Diamines. J. Org. Chem. 2017, 82, 8273-8281.

(28) Duan, Y.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y.-C. Fe-Catalyzed insertion of fluoromethylcarbenes generated from sulfonium salts into X–H bonds (X = Si, C, P). Org. Chem. Front. 2017, 4, 1917-1920.

(29) Duan, Y.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y.-C. Difluoromethylcarbene for iron-catalyzed cyclopropanation. Chem. Commun. 2017, 53, 3870 - 3873.

(30) Zheng, Q.-T.; Wei, Y.; Zheng, J.; Duan, Y.-y.; Zhao, G.; Wang, Z.-B.; Lin, J.-H.;* Zheng, X.;* Xiao, J.-C.* Difluoromethylation of N-arylsulfonyl hydrazones with difluorocarbene leading to difluoromethyl aryl sulfones. RSC Adv. 2016, 6, 82298-82300.

(31) Liu, C.; Deng, X.-Y.; Zeng, X.-L.; Zhao, G.; Lin, J.-H.;* Wang, H.;* Xiao, J.-C.* Base-free O-difluoromethylation of 1,3-diones with difluorocarbene. J. Fluorine Chem. 2016, 192, 27-30.

(32) Ji, Y.-L.; Luo, J.-J.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y. C. Cu-Catalyzed C-H Trifluoromethylation of 3-Arylprop-1-ynes for the Selective Construction of Allenic Csp(2)-CF3 and Propargyl Csp(3)-CF3 Bonds. Org. Lett. 2016, 18, 1000-1003.

(33) Duan, Y.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y. C. A Trifluoromethylcarbene Source. Org. Lett. 2016, 18, 2471-2474.

(34) Deng, Z.; Liu, C.; Zeng, X.-L.; Lin, J.-H.; * Xiao, J.-C. * Nucleophilic 1,1-Difluoroethylation with Fluorinated Phosphonium Salt. J. Org. Chem. 2016, 81, 12084 - 12090.

(35) Lin, J.-H.; Ji, Y.-L.; Xiao, J.-C.* Recent Advances in C-H Trifluoromethylthiolation and Trifluoromethoxylation Reactions. Curr. Org. Chem. 2015, 19, 1541-1553.

(36) Lin, J.-H.; Xiao, J.-C.* Recent advances in asymmetric fluorination and fluoroalkylation reactions via organocatalysis. Tetrahedron Lett. 2014, 55, 6147-6155.

(37) Ji, Y.-L.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y.-C. Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes. Org. Chem. Front. 2014, 1, 1280-1284.

(38) Ji, Y.-L.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y.-C. Stereoselective Synthesis of α-Trifluoromethyl Enones by AuI/CuI-Co-Catalyzed Tandem 1,3-Acyloxy Migration/Trifluoromethylation Reaction of Propargyl Acetates. Eur. J. Org. Chem. 2014, 7948-7954.

(39) Ji, Y.-L.; Kong, J.-J.; Lin, J.-H.;* Xiao, J.-C.;* Gu, Y.-C. Copper-mediated trifluoromethylation of propargyl acetates leading to trifluoromethyl-allenes. Org. Biomol. Chem. 2014, 12, 2903-2906.

(40) Lin, J.-H.; Zong, G.; Du, R.-B.; Xiao, J.-C.;* Liu, S. The asymmetric synthesis of CF3- or -CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst. Chem. Commun. 2012, 48, 7738-7740.

(41) Lin, J.-H.; Xiao, J.-C.* The Asymmetric Friedel-Crafts Reaction of Indoles with Fluoroalkylated Nitroalkenes Catalyzed by Chiral Phosphoric Acid. Eur. J. Org. Chem. 2011, 2011, 4536-4539.

(42) Lin, J.-H.; Zhang, C.-P.; Zhu, Z.-Q.; Chen, Q.-Y.; Xiao, J.-C.* A novel pyrrolidinium ionic liquid with 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate anion as a recyclable reaction medium and efficient catalyst for Friedel–Crafts alkylations of indoles with nitroalkenes. J. Fluorine Chem. 2009, 130, 394-398.

(43) Lin, J.-H.; Zhang, C.-P.; Xiao, J.-C.* Enantioselective aldol reaction of cyclic ketones with aryl aldehydes catalyzed by a cyclohexanediamine derived salt in the presence of water. Green Chem. 2009, 11, 1750-1753.


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