报告题目 (Title)：Supramolecular Phototherapy
报告人 (Speaker)： 张 希
报告时间 (Time)：2024年5月11日 9:30-10:00
报告地点 (Place)：校本部 乐乎新楼学海厅
邀请人(Inviter)：李 健 教授 于 洋 教授
主办部门：理学院化学系
报告摘要：
Phototherapy, including photodynamic therapy and photothermal therapy, is an indispensable light-induced method for cancer therapies and curing bacterial infections. Even though phototherapy has been utilized in clinical applications, it possesses some shortcomings such as side effects to normal tissues and relatively low efficiencies. Supramolecular phototherapy aims to employ supramolecular strategies for tuning the activity and selectivity of photoactive reagents, thus improving the efficiency of phototherapy.
We employed the steric effect of cucurbit[7]uril (CB[7]) to diminish the aggregation of a porphyrin derivative through host-guest complexation. By forming the supramolecular photosensitizer, the singlet oxygen quantum yield was greatly increased owing to the suppression of self-quenching. As a result, the supramolecular photosensitizer showed a significantly improved antibacterial activity under mild white light irradiation and a highly efficient antibacterial photodynamic therapy could be achieved.
We also employed the electrostatic effect of CB[7] to stabilize the radical anion of a derivative of perylene diimide (PDI). The supramolecular PDI radical anion became an effective near infrared system with enhanced photothermal conversion efficiency. It was interestingly found that the supramolecular complex of PDI and CB[7] could be selectively reduced to form the supramolecular PDI radical anion by facultative anaerobic bacteria as well as hypoxic tumors in situ. Therefore, the selective photothermal therapy could be realized by the efficient photothermal conversion of the supramolecular PDI radical anion under near-infrared irradiation.
It is highly anticipated that supramolecular strategies can be extended to many other photoactive reagents, thus bringing a new horizon of phototherapy.
References
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[2] Y. Jiao, K. Liu, G. Wang, Y. Wang, X. Zhang, Chem. Sci.2015, 6, 3975.
[3] Y. Yang, P. He, Y. Wang, H. Bai, S. Wang, J.-F. Xu, X. Zhang, Angew. Chem. Int. Ed. 2017, 56, 16239.
[4] H. Wang, K.-F. Xue, Y. Yang, H. Hu, J.-F. Xu, X. Zhang, J. Am. Chem. Soc. 2022, 144, 2360.
报告人简介：
张希，高分子化学家，中国科学院院士，清华大学化学系教授、博士生导师，主要从事超分子组装、有序分子薄膜及单分子力谱等方面的研究，致力于将高分子化学与物理同超分子化学相结合, 赋予超分子新内涵，并开拓高分子研究新方向。张希1982年考入吉林大学化学系，先后获学士、硕士、博士学位；1991年作为吉林大学和德国美因茨大学联合培养的博士生前往德国学习；1992年开始在吉林大学化学系任教，先后担任讲师、教授、博士生导师；1993年进入吉林大学超硬材料国家重点实验室进行博士后工作；1994年入选原国家教委“优秀跨世纪人才计划”；1997年担任超分子结构与材料国家重点实验室主任，同年获得国家杰出青年科学基金资助；1998年获得香港求是杰出青年学者奖；2004年进入清华大学化学系工作，担任教授、博士生导师；2007年当选为中国科学院院士；2008年担任清华大学化学系主任；2011年被评为北京市优秀共产党员；2014年担任国家自然科学基金委员会化学部主任，同年出任清华大学学术委员会主任；2016年当选为美国化学会会士，同年获得何梁何利基金科学与技术进步奖 。