办公室：生命科学楼517

职称：副教授 东方学者

学历：博士研究生

电话：021-6613 5155; 138-1716-8483

Email：chlei@shu.edu.cn

【个人简历】

2004.09 — 2008.07 北京师范大学化学学院 理学学士

2008.09 — 2014.01 中国科学院化学研究所(保送) 理学博士 导师王梅祥 院士

2014.02 — 2014.06 康龙化成（北京）新药技术股份有限公司 有机合成高级研究员

2014.07 — 2017.12 新加坡南洋理工大学化学与化学生物学系 Research Fellow 合作导师Jianrong Steve Zhou

2018.01 — 目前 上海大学理学院化学系 特聘研究员、副教授

【科研项目】

1. 具有稳定自由基性质的新型扩展卟啉的设计、合成及性能研究，国家自然科学基金面上项目（22171179），主持，2022.01-2025.12

2. 对酸具有响应性的新型扩展卟啉的设计、合成及其在生物医学中的应用研究，上海市“科技创新行动计划”启明星计划（20QA1403700），主持，2020.06-2023.12

3. 具有质子耦合电子转移性质的新型扩展卟啉超分子主体的构建及其合成应用研究，国家自然科学基金青年基金（21901155），主持，2020.01-2022.12

4. 上海市教委青年教师科研专项基金，主持，2020.01-2022.12

5. 上海市高校特聘教授（东方学者）主持，2019.07-2022.08

【论文著作】

1. Yang, L.; Lei, C.-H.; Wang, D.-X.; Huang, Z.-T.; Wang, M.-X.* Highly Efficient and Expedient Synthesis of 5-Hydroxy-1H-pyrrol-2-(5H)-ones from FeCl₃-Catalyzed Tandem Intramolecular Enaminic Addition of Tertiary Enamides to Ketones and 1,3-Hydroxy Rearrangement. Org. Lett. 2010, 12, 3918-3921.

2. Lei, C.-H.; Wang, D.-X.; Zhao, L.; Zhu, J.; Wang, M.-X.* Synthesis of Substituted Pyridines from Cascade [1+5] Cycloaddition of Isonitriles to N-Formylmethyl-substituted Enamides, Aerobic Oxidative Aromatization, and Acyl Transfer Reaction. J. Am. Chem. Soc. 2013, 135, 4708-4711.

3. Lei, C.-H.; Wang, D.-X.; Zhao, L.; Zhu, J.; Wang, M.-X.* Synthesis of Multifunctionalized 1,2,3,4-Tetrahydropyridines, 2,3-Dihydropyridin-4(1H)-ones and Pyridines from Tandem Reactions Initiated by [5+1] Cycloaddition of N-Formylmethyl-Substituted Enamides to Isocyanides: Mechanistic Insight and Synthetic Application. Chem. Eur. J. 2013, 19, 16981-16987.

4. Lei, C.-H.; Zhao, L.; Wang, D.-X.; Zhu, J.; Wang, M.-X.* Functionalized Imidazoliniums from the Three-component Domino Reaction of N-Formylmethylcarboxamides with Amines and Isocyanides. Org. Chem. Front. 2014, 1, 909-913.

5. Wu, X.; Lei, C.; Yue, G.; Zhou, J. S.* Palladium-Catalyzed Direct Cyclopropylation of Heterocycles. Angew. Chem. Int. Ed. 2015, 54, 9601-9605.

6. Lei, C.; Jin, X.; Zhou, J. S.* Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides. Angew. Chem. Int. Ed. 2015, 54, 13397-13400.

7. Lei, C.; Jin, X.; Zhou, J. S.* Palladium-catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides. ACS Catalysis 2016, 6, 1635-1639.

8. Lei, C.;^§ Cao, J.;^§ Zhou, J. S.* Palladium-catalyzed Arylation of Ketones and Acetonitrile with ortho-Alkylation of Aryl Rings: de novo Synthesis of Tetralines and Benzocycloheptenes. Org. Lett. 2016, 18, 6120-6123.

9. Lei, C.; Yip, Y. J.; Zhou, J. S.* Nickel-Catalyzed Direct Synthesis of Aryl Olefins from Ketones and Organoboron Reagents under Neutral Conditions. J. Am. Chem. Soc. 2017, 139, 6086-6089.

(After joining in Shanghai University)

10. Xu, X.-M.;^§ Lei, C.-H.;^§ Tong, S.; Zhu, J.; Wang, M.-X.* Lewis Acid Catalyst-steered Divergent Synthesis of Functionalized Vicinal Amino Alcohols and Pyrroles from Tertiary Enamides. Org. Chem. Front. 2018, 5, 3138-3142. (co-first author).

11. Wang, F.; Sikma, E.; Duan, Z.; Sarma, T.; Lei, C.; Zhang, Z.; Humphrey, S. M.; Sessler, J. L. Shape-persistent Pyrrole-based Covalent Organic Cages: Synthesis, Structure and Selective Gas Adsorption Properties. Chem. Commun. 2019, 55, 6185-6188.

12. Meng, F.; Zhang, X.; Sarma, T.; Yuan, N.; Yin, Y.; Duan, Z.; Lei, C.;* Qian, Q.;* Ding, L.;* Zhang, Z.* A Poly(pyridine-pyrrole) Foldamer that Binds Isolated Water Molecules. CrystEngComm 2019, 21, 3906-3909.

13. Lei, C.; Zhu, D.; Tangcueco, V. I. T.; Zhou, J. S.* Arylation of Aldehydes to Directly Form Ketones via Tandem Nickel Catalysis. Org. Lett. 2019, 21, 5817-5822. DOI: 10.1021/acs.orglett.9b01782.

14. Ye, D.; Liu, Z.; Chen, H.; Sessler, J. L.;* Lei, C.* Cesium Carbonate Catalyzed Esterification of N-Benzyl-N-Boc Amides under Ambient Conditions. Org. Lett. 2019, 21, 6888-6892.

15. Liu, J.; Lei, C.;* Gong, H.* Nickel-catalyzed reductive coupling of glucosyl halides with aryl/vinyl halides enabling β-selective preparation of C-aryl/vinyl glucosides. Sci. China Chem. 2019, 62, 1492-1496.

16. Zhu, Q.; Meng, B.; Gu, C.; Xu, Y.; Chen, J.; Lei, C.;* Wu, X.* Diastereo- and Enantioselective Synthesis of Quaternary alpha-Amino Acid Precursors by Copper-Catalyzed Propargylation. Org. Lett. 2019, 21, 9985-9989.

17. Wang, F.; Sikma, E.; Duan, Z., Lei, C.; Zhang, Z.;* Humphrey, S. M.;* Sessler, J. L.;* Dipyrrolylnaphthyridine-based Schiff-base Cryptands and Their Selective Gas Adsorption Properties. J. Porphyr. Phthalocya. 2020, 24, 424-431.

18. Wang, F.; Sen, S.; Chen, C.; Bähring, S.;* Lei, C.;* Duan, Z.; Zhang, Z.;* Sessler, J. L.;* Jana, A.* Self-Assembled Cagelike Receptor That Binds Biologically Relevant Dicarboxylic Acids via Proton-Coupled Anion Recognition. J. Am. Chem. Soc. 2020, 142, 1987-1994.

19. Xia, S.; Hu, K.; Lei, C.;* Jin, J.* Intramolecular Aromatic C–H Acyloxylation Enabled by Iron Photocatalysis. Org. Lett. 2020, 22, 1385-1389.

20. Kim, T.; Duan, Z.; Talukdar, S.; Lei, C.;* Kim, D.;* Sessler, J. L.;* Sarma, T.* Excitonically Coupled Cyclic BF₂ Arrays of Calix[8]- and Calix[16]phyrin as Near-IR-Chromophores. Angew. Chem. Int. Ed. 2020, 59, 13063-13070.

21. Ma, G.; Chen, C.; Talukdar, S.; Zhao, X.; Lei, C.;* Gong, H.* Metal catalyst-free photo-induced alkyl C-O bond borylation. Chem. Commun. 2020, 56, 10219-10222.

22. Ye, D.; Liu, Z.; Sessler, J. L.;* Lei, C.* Base-free oxidation of alcohols enabled by nickel(II)-catalyzed transfer dehydrogenation. Chem. Commun. 2020, 56, 11811-11814.

23. Sun, D.; Ma, G.; Zhao, X.; Lei, C.;* Gong, H.* Nickel-catalyzed asymmetric reductive arylation of alpha-chlorosulfones with aryl halides. Chem. Sci. 2021, 12, 5253-5258.

24. Ye, D.; Chen, H.; Liu, Z.; Lei, C.* Transamidation of N-benzyl-N-Boc Amides under Transition Metal-free and Base-free Conditions. Chin. J. Org. Chem. 2021, 41, 1658-1669.

25. Lu, S.; Ren, X.; Guo, T.; Cao, Z.; Sun, H.; Wang, C.; Wang, F.; Shu, Z.; Hao, J.; Gui, S.; Lei, C.;* Zhang, J.* Controlled release of iodine from cross-linked cyclodextrin metal-organic frameworks for prolonged periodontal pocket therapy. Carbohydr. Polym. 2021, 267, 118187.

26. Yang, G.; Li, P.; Liu, Z.; Wu, S.; Zhuang, C.; Qiao, H.; Zheng, L.; Fang, P.; Lei, C.; Wang, J.* Structural basis for the dimerization mechanism of human transcription factor E3. Biochem. Biophys. Res. Commun. 2021, 569, 41-46.

27. Zhou, W.; Hao, M.; Lu, T.; Duan, Z.; Sarma, T.;* Sessler, J. L.;* Lei, C.* Carbazole-Containing Carbadecaphyrins: Non-aromatic Expanded Porphyrins that Undergo Proton-Triggered Conformational Changes. Chem. Eur. J. 2021, 27, 16173-16180.

28. Zhou, W.; Sarma, T.; Su, Y.; Lei, C.;* Sessler, J. L.* Kinetic trapping of a cobalt(II) metallocage using an carbazole-containing expanded carbaporphyrinoid ligand. Chem. Sci. 2022, 13, 692-697.

29. Su, M.; Huang, X.; Lei, C.;* Jin, J.* Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent. Org. Lett. 2022, 24, 354-358.

30. Zheng, Y.;^§ Wang, X.;^§ Chen, H.; Lu, T.; Duan, Z.; Lei, C.* 1,4-Phenylene-Incorporated Decaphyrin(1.0.1.0.0.1.0.1.0.0): Synthesis, Structure, and Topological Chirality. Org. Lett. 2022, 24, 2509-2514.

31. Chen, H.; Shi, X.; Lun, Y.; Xu, Y.; Lu, T.; Duan, Z.; Shao M.; Sessler, J. L.;^* Yu, H.;^* Lei, C.^* 3,6-Carbazoylene Octaphyrin (1.0.0.0.1.0.0.0) and Its Bis-BF₂ Complex. J. Am. Chem. Soc. 2022, 144, 8194–8203.

32. Zhou, W.; Sarma, T.; Yang, L.; Lei, C.;^* Sessler, J. L.^* Controlled assembly of a bicyclic porphyrinoid and its 3-dimensional boron difluoride arrays. Chem. Sci. 2022, 13, 7276-7282.

33. Deng, X.; Huang, J.; Wang, G.; Li, J.; Li, X.; Lei, C.;^* Zhang, K.^* Enhancing room-temperature phosphorescence via intermolecular charge transfer in dopant-matrix systems. Chem. Commun. 2022, 58, 8137-8140.

34. Huang, J.; Wang, X.; Wang, G.; Li, J.; Deng, X.; Chen, X.; Xu, Y.; Lei, C.;* Zhang, K.* Polymer-Based TADF-Type Organic Afterglow. J. Phys. Chem. C 2022, 126, 20728-20738.

35. Liang, K.; Chen, H.; Wang, X.; Lu, T.; Duan, Z.; Sessler, J. L.;* Lei, C.* Di-2,7-pyrenidecaphyrin(1.1.0.0.0.1.1.0.0.0) and Its Bis-Organopalladium Complexes: Synthesis and Chiroptical Properties. Angew. Chem. Int. Ed. 2023, 62, e202212770.

36. Wang, X.;^§ Zheng, Y.;^§ Han, M.; Zhang, H.; Duan, Z.; Shao, M.; Jia, J.; Lei, C.* 1,4-Phenylene incorporated decaphyrin tetrarhodium(I) complex: synthesis, structures and chiroptical properties. J. Porphyr. Phthalocya. 2023, DOI: 10.1142/S1088424623500220.

【申请专利】

1. 王梅祥，雷川虎，王德先。多取代二氢吡啶-4-酮类化合物及其制备方法与应用。申请号：CN 201310134018.6，授权公告号：CN 104109113B.

【荣誉获奖】

2020 上海市2020年度“启明星”计划

2018 上海市高校特聘教授（东方学者）

2012 中科院化学所青年科学优秀奖