【教育及工作经历】

1996-2000     浙江大学，学士

2000-2005     中科院上海有机化学研究所，博士

2006-2008     新加坡国立大学，博士后

2008-2009     上海大学工作，讲师

2009-2015     上海大学，副教授

2015-至 今     上海大学，教授

【讲授课程】

有机化学、有机化学实验、药物化学、不对称合成

【研究方向】

不对称催化；医药中间体合成工艺开发

【科研项目】

1. 国家自然科学基金青年基金项目(No. 20802043)：不对称有机小分子催化反应及其应用的研究

2. 国家自然科学基金面上项目(No. 21072125)：基于不对称有机催化的串联反应的设计

3. 国家自然科学基金面上项目(No. 21272150): 有机催化构筑手性吲哚螺环结构及其在合成中的应用研究

4. 国家自然科学基金面上项目(No. 21672137): 基于带亲核位点端炔丙醇类底物的不对称催化串联环化反应

5. 国家自然科学基金面上项目(No. 21971158): 双核铜手性配合物及其在不对称催化中应用研究

【申请专利】

1. (E)- 4.4-二甲氧基-2-丁烯醛的制备方法，CN101967087A

2. 铜催化制备2‑甲基咪唑并[1,2‑a]吡啶类化合物的方法，CN106831767A

3. 9-去氮鸟嘌呤合成工艺的改进方法，CN110590786A

4. 氮掺杂碳基催化剂及其在催化乙炔氢氯化反应制备氯乙烯中应用，CN111715258A

5. (E)-3-(3-氯-2-氟-6-(1H-四氮唑-1-基)苯基)丙烯酸的合成方法，CN112409281A

【论文著作】

1. Wang, J.; Zhang, S.; Ding, W. Z.; Wang, C. H.; Chen, J.; Cao, W. G.; Wu, X. Y. "Amide-phosphonium Salt Catalyzed Enantioselective Vinylogous Mannich Addition of Coumarins to Isatin Imines", ChemCatChem 2020, 12, 444 (IF 4.495)

2. Zhu, Q. Q.; Meng, B. B.; Gu, C. Z.; Xu, Y.; Chen, J.; Lei, C. H.; Wu, X. Y. "Diastereo- and Enantioselective Synthesis of Quaternary α‑Amino Acid Precursors by Copper-Catalyzed Propargylation", Org. Lett. 2019, 21, 9985 (IF 6.364)

3. Xia, X. J.; Zhu, Q. Q.; Wang, J.; Chen, J.; Cao, W. G.; Zhu, B.; Wu, X. Y. "Direct Asymmetric Vinylogous Mannich Addition of 3,5-Disubstituted-4-nitroisoxazoles to Isatin-Derived Imines Catalyzed by a Bifunctional Phase-Transfer-Catalyst", J. Org. Chem. 2018, 83, 14617 (IF 4.721)

4. Chen, H.; Lu, X. H.; Xia, X. J.; Zhu, Q. Q.; Song, Y. H.; Chen, J.; Cao, W. G.; Wu, X. Y. "Asymmetric Catalytic [4 + 2] Cycloaddition via Cu−Allenylidene Intermediate: Stereoselective Synthesis of Tetrahydroquinolines Fused with a γ‑Lactone Moiety", Org. Lett. 2018, 20, 1760 (IF 6.364)

5. Lu, X. H.; Ge, L.; Cheng, C.; Chen, J.; Cao, W. G.; Wu, X. Y. " Enantioselective Cascade Reaction for Synthesis of Quinolinones through Synergistic Catalysis Using Cu–Pybox and Chiral Benzotetramisole as Catalysts", Chem. Eur. J., 2017, 23, 7689 (IF 5.731)

6. Cheng, C.; Lu, X. H.; Ge, L.; Chen, J.; Cao, W. G.; Wu, X. Y.; Zhao, G. "Effective asymmetric vinylogous Mannich reaction of isatin imines with α,α-dicyanoolefins in the presence of a simple chiral amide phosphonium bifunctional phase transfer catalyst", Org. Chem. Front., 2017, 4, 101 (IF 4.693)

7. Ge, L.; Lu, X. H.; Cheng, C.; Chen, J.; Cao, W. G.; Wu, X. Y.; Zhao, G. "Amide-Phosphonium Salt as Bifunctional Phase Transfer Catalyst for Asymmetric 1,6-Addition of Malonate Esters to para-Quinone Methides", J. Org. Chem. 2016, 81, 9315 (IF 4.721)

8. Cheng, C.; Ge, L; Lu, X. H.; Huang, J. P.; Huang, H. C.; Chen, J.; Cao, W. G.; Wu, X. Y. "Cu-Pybox catalyzed synthesis of 2,3-disubstituted imidazo[1,2-a] pyridines from 2-aminopyridines and propargyl alcohol derivatives", Tetrahedron 2016, 72, 6866 (IF 2.641)

9. Huang, G. X.; Cheng, C.; Ge, L.; Guo, B. B.; Zhao, L.; Wu, X. Y. "Trialkyl Methanetricarboxylate as Dialkyl Malonate Surrogate in Copper-Catalyzed Enantioselective Propargylic Substitution", Org. Lett. 2015, 17, 4894 (IF 6.364)

10. Guo, B. B.; Ge, L.; Huang, G. X.; Zhao, L.; Chen, J.; Cao, W. G.; Wu, X. Y. "Expedient Introduction of b-Methoxyacrylate Unit onto 3-Substituted Indoles and Application of the Resulting Indole-Dienes in Organocascade toward Indolino-Polycyclics", Adv. Synth. Catal. 2015, 357, 4013 (IF 5.663)

11. Zhao, L.; Huang, G. X.; Guo, B. B.; Xu, L. J.; Chen, J.; Cao, W. G.; Zhao, G.; Wu, X. Y. "Diastereo- and Enantioselective Propargylation of Benzofuranones Catalyzed by Pybox-Copper Complex", Org. Lett. 2014, 16, 5584 (IF 6.364)

12. Zhao, L.; Guo, B. B.; Huang, G. X.; Chen, J.; Cao, W. G.; Wu, X. Y. "Enantioselective Formation of 3‑Substituted Indolinoazepines via Organocatalyzed Conjugate Addition of Indoloazepines to Propargyl Aldehyde", ACS, Catal. 2014, 4, 4420 (IF 9.314)

13. Wu, X. Y.; Huang, J. B.; Guo, B. B.; Zhao, L.; Liu, Y.; Chen, J.; Cao, W. G. " Enantioselective Michael/aza-Michael/Cyclization Organocascade to Tetracyclic Spiroindolines: Concise Total Synthesis of Kopsinine and Aspidofractine", Adv. Synth. Catal. 2014, 356, 3377 (IF 5.663)

14. Huang, J. B.; Zhao, L.; Liu, Y.; Cao,W. G.; Wu, X. Y.; "Enantioselective Intermolecular Formal [3 + 3] Cycloaddition of 2,3-Disubstituted Indoles with Acrolein", Org. Lett. 2013, 15, 4338 (IF 6.364)

15. Wu, X. Y., Liu, Q.; Liu, Y.; Wang, Q.; Zhang, Y.; Chen, J.; Cao, W. G.; Zhao, G.; "Amino Acid-Derived Phosphonium Salts-Catalyzed Michael Addition of 3-Substituted Oxindoles", Adv. Synth. Catal. 2013, 355, 2701 (IF 5.663)

16. Liu, Y.; Wang, Q.; Zhang, Y.; Huang, J. B.; Nie, L. L.; Chen, J.; Cao, W. G.; Wu, X. Y.; "Enantioselective Synthesis of Indoloquinolizidines via Asymmetric Catalytic Hydrogenation/Lactamization of Imino Diesters", J. Org. Chem. 2013, 78, 12009 (IF 4.721)

17. 陈杰, 刘钦, 戴小鸯, 聂凛凛, 房辉辉, 吴小余, "不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应研究进展", 有机化学 2013, 1, 1 (IF 0.991)

18. Wu, X. Y.; Liu, Q.; Fang, H. H.; Chen, J.; Cao, W. G.; Zhao, G. "Enantioselective Organocatalyzed Cascade Reactions to Highly Functionalized Spirotetracyclic Indolenines and Oxindoles", Chem. Eur. J. 2012, 18, 12196 (IF 5.731)

19. Wu, X. Y.; Dai, X. Y.; Fang, H. H.; Nie, L. L.; Chen, J.; Cao, W. G.; Zhao, G. "One-Pot Three-Component Syntheses of Indoloquinolizidine Derivatives Using an Organocatalytic Michael Addition and Subsequent Pictet–Spengler Cyclization", Chem. Eur. J. 2011, 17, 10510 (IF 5.731)

20. Wu, X. Y.; Nie, L. L.; Fang, H. H.; Chen, J.; Cao, W. G.; Zhao, G. "Organocatalyzed Cascade Reactions of Cyclic β-Enamino Esters and α,β-Unsaturated Aldehydes Leading to Indoloquinolizidines and Benzoquinolizidines", Eur. J. Org. Chem. 2011, 6755 (IF 3.065)

21. Wu, X. Y.; Zhang, Y.; Dai, X. Y.; Fang, H. H.; Chen, J.; Cao, W. G.; Zhao, G. "Enantioselective Cascade Sequence to Indoloquinolizidines and Its Application in the Synthesis of epi-Geissochizol", Synthesis 2011, 3675 (IF 2.689)

22. Wu, X. Y.; Fang, H. H.; Liu, Q.; Nie, L. L.; Chen, J.; Cao, W. G.; Zhao, G. "Diastereoselective Cascade Reactions Toward Substituted Diazaindeno[2,1-a] Phenanthrenes", Tetrahedron 2011, 67, 7251 (IF 2.641)

23. Dai, X. Y.; Wu, X. Y.; Fang, H. H.; Nie, L. L.; Chen, J.; Deng, H. M.; Cao, W. G.; Zhao, G. "Enantioselective organocatalyzed cascade reactions to highly functionalized quinolizidines", Tetrahedron 2011, 67, 3034 (IF 2.641)

24. Fang, H. H.; Wu, X. Y.; Nie, L.; Dai, X.; Chen, J.; Cao, W.; Zhao, G. "Diastereoselective Syntheses of Indoloquinolizidines by a Pictet-Spengler/Lactamization Cascade", Org. Lett. 2010, 12, 5366 (IF 6.364)

25. Xu, J. C.; Wei, J. M.; Bian, L. L.; Zhang, J. P.; Chen, J.; Deng, H. M.; Wu, X. Y.; Zhang, H.; Cao, W. G. "First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl- 1H-1,5-benzodiazepines via a catalyst-free three-component reaction", Chem. Commun. 2011, 47, 3607 (IF 6.834)

26. Wu, X. Y.; Dai, X. Y.; Nie, L. L.; Fang, H. H.; Chen, J.; Ren, Z. J.; Cao, W. G.; Zhao, G. "Organocatalyzed Enantioselective One-pot Three-component Access to Indoloquinolizidines by a Michael Addition-Pictect-Spengler Sequence", Chem. Commun. 2010, 46, 2733 (IF 6.834)

27. Wu, X. Y.; Ma, Z. X.; Ye, Z. Q.; Qian, S.; Zhao. G. "Highly Efficient Organocatalyzed Direct Asymmetric Aldol Reactions of Hydroxyacetone and Aldehydes", Adv. Synth. Catal. 2009, 351, 158 (IF 5.663)

28. Wu, X. Y.; Cao, W. G.; Zhang, H.; Chen, J.; Jiang, H. Y.; Deng, H. M.; Shao, M.; Zhang, J. P.; Chen. H. Y. "Highly Stereoselective Synthesis of β,γ-Disubstituted and α,β,γ-Trisubstituted Butyrolactones", Tetrahedron 2008, 64, 10331 (IF 2.641)