郦鑫耀，教授，博导，xinyaoli@shu.edu.cn

课题组网站：https://www.x-mol.com/groups/xinyao_li

ORCID: https://orcid.org/0000-0001-5230-782X

【研究领域】

近几年来一直致力于有机催化合成和理论计算研究，包括：1.不对称光催化反应；2.过渡金属催化反应；3.自由基反应；4. 氨基酸修饰；5. DFT理论计算研究反应机理等

迄今已经在国际学术期刊Chem, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Org. Lett.等上发表论文50余篇

【教育经历】

2013.9‒2016.7    博士   北京大学   药物化学（导师：焦宁教授）

2007.9‒2013.7   学士，硕士  北京化工大学  应用化学（导师：许家喜教授）

【工作经历】

2021.03‒至 今       教授，博导  上海大学  理学院化学系

2017.10‒2020.08  博士后  慕尼黑工业大学  有机化学（导师：Prof. Thorsten Bach）

2016.08‒2017.07  研究助理  北京大学  药物化学

【主要奖励和荣誉】

2022年 Thieme Chemistry Journal Award国际学术奖

2021年 上海市海外高层次人才，浦江人才

2020年 北京市自然科学奖一等奖（排名8/8）

2017年 德国洪堡奖学金

【代表性科研项目】

1. 上海市海外高层次人才计划，2021.03-2024.12, 结题

2. 上海市浦江(A类)人才计划，2021.10-2023.09, 结题

3. 国家自然科学基金青年项目，2022.01-2024.12, 结题

4. 国家自然科学基金面上项目，2026.01-2029.12, 主持，在研

【代表性学术论文】

17. Du, T.; Qin, Q.; Li, J.; Shen, Y.; Wang, Z.; Yin, K.*; Li, X. Y.*; Li, J.*; Zhou, Z. J.* Rhodium-catalyzed cycloaddition of bicyclo[1.1.0] butanes with N,N’-cyclic azomethine imines: en route to fused diaza-3D scaffolds. Org. Chem. Front. 2025, DOI: 10.1039/d5qo01147g.

16. Yang, H.; Li, X. Y.* Decarboxylative Alkylation of Difluoroenoxysilanes via VisibleLight-Excited EDA Complex. Eur. J. Org. Chem. 2025, 28, e202500540.

15. Hai, J.; Li, H.; Li, Y.; Li, X. Y.* Green-Light Photocatalytic Synthesis of Non-Proteinogenic Isothiocyanate-Decorated Amino Acids from Lysine Residues and Carbon Disulfide. Adv. Synth. Catal. 2025, 367, e70002.

14. Wu, F.; Huang, K.; Cen, Z.; Yan, C.; Kan, Y.*; Li, X. Y.*; Wu, X.Y.* Diastereo- and Enantioselective Allylation of α‑Hydroxy Ketones Enabled by Palladium/Borinic Acid Dual Catalysis. ACS Catal. 2025, 15, 8586−8598.

13. Wan, Z.; Gu, J.;Lu, Y.; Tian, X.; Zeng, Z.; Yan, Y.; Li, X. Y.*; Zhuang, D.*; Li, Z. Y.* Selective Benzylic Cross-Dehydrogenative Arylation and α,β Dehydrogenation Under Mild Conditions. Org. Chem. Front. 2025, 12, 3594–3605.

12. Cheng, Z.; Huang, K.; Wang, C.; Chen, L.; Li, X. Y.; Hu, Z.; Shan, X.; Cao, P.-F.; Sun, Ha.; Chen, W.; Li, C.; Zhang, Z.; Tan, H.; Jiang, X.; Zhang, G.; Zhang, Z.; Lin, M.; Wang, L.; Zheng, A.; Xia, C.*; Wang, T.; Song, S.; Shu, X.; Jiao, N.* Catalytic remodeling of complex alkenes to oxonitriles through C=C double bond deconstruction. Science 2025, 387, 1083–1090.

11. Qiu, S.; Yu, X.; Guo, H.; Li, J.*; Li, X. Y.*; Xu, P.* Photocatalytic Radical Bis(trifluoromethyl)carbinolation of Alkenes and Heteroarenes. Angew. Chem. Int. Ed. 2025, e202424757.

10. Ling, S.; Hai, J.; Li, X. Y.* Visible-light-mediated C–S bond activation in cysteine derivatives with quinoxalinones for the synthesis of heteroaryl amino acids. Org. Chem. Front. 2025, 12, 2018–2024.

9. Fei, Y.; Zhou, Z.; Ni, Z.; Peng, X.; Cui, L.*; Zhou, Z.; Li, X. Y.*; Li, C.; Jia, X.; Li, J.* Chemoselective Construction of Polycyclic Heterocycles Containing a [6-6-5] or [7-6-5] Tricyclic Core Skeleton from a 2-Isocyanophenyl Propargylic Ester. Angew. Chem. Int. Ed. 2025, 64, e202414726.

8. Lu, D.; Lu, S.; Ding C.-H.; Li, X. Y.*; Xu, B.* Synthesis of β‑Carbonyl α‑Iminoamides by Double Insertion of Isocyanides into Aldehydes. Org. Lett. 2024, 26, 6335−6340.

7. Zhuang, D.; Cheng, L.; Yan, Y.; Tang, Y.; Wang, Z.; Gu, J.; Lu, Y.; Li, X. Y.*; Li, Z. Y.* Three-component formal metathesis via remote activating strategy enabled (RASE) domino activation of two C(sp3)–O bonds in alkyl ethers. Org. Chem. Front. 2024, 11, 4138–4148.

6. Wu, L.;Huang, Z. Y.*; Miao, J.; Wang, S.; Li, X. Y.*; Li, N.; Cao, X.; Yang, C. L.* Orienting Group Directed Cascade Borylation for Efficient One-Shot Synthesis of 1,4-BN-Doped Polycyclic Aromatic Hydrocarbons as Narrowband Organic Emitters.Angew. Chem. Int. Ed. 2024, 63, e202402020.

5. Li, Y.; Li, X. Y.* Theoretical insights into the enantiodivergence induced by chiral phosphoric acid catalysis with a Lewis acid for the synthesis of N–N axially chiral atropisomers. Org. Biomol. Chem. 2024, 22, 1654–1661.

4. Deng, Y.; Yang, Z.; Li, Y.; Li, X. Y.*; Xu, B.* Copper nitrate-enabled ring expansion reaction of cyclopropanes: a direct approach to 3-cyano-isoxazoline N-oxides. Org. Chem. Front. 2024, 11, 1404–1411.

3. Zhang, K.; Huang, Q.; Yang, C.; Li, X. Y.* Theoretical Insights into the Regiodivergence in Ni-Catalyzed [2+2+2] Cycloaddition of Unsymmetric Diynes and CO₂. Inorganics 2024, 12, 39.

2. Huang, Q.; Li, Y.; Yang, C.; Wu, W.; Hai, J.; Li, X. Y.* Atroposelective synthesis of N–N axially chiral pyrrolyl(aza)-quinolinone by de novo ring formation. Org. Chem. Front. 2024, 11, 726–734.

1. Yang, C.; Li, Y.; Huang, Q.; Li, X. Y.* Lewis Acid Catalyzed [4+1] Cycloaddition of o-Quinone Methides and Isocyanides: Mild and Efficient Synthesis of 3-Aryl-2-amino benzofurans. Synlett 2023, 34, 1230–1234.

Before SHU

1. Li, X. Y.; Großkopf, J.; Jandl, C.; Bach, T. Enantioselective Visible Light-mediated Aza-Paternò-Büchi Reactions of Quinoxalinones. Angew. Chem. Int. Ed. 2021, 60, 2684–2688.

2. Li, X. Y.; Kutta, R. J.; Jandl, C.; Bauer, A.; Nuernberger, P.; Bach, T. Photochemically Induced Ring Opening of Spirocyclopropyl Oxindoles: Evidence for a Triplet 1,3-Diradical Intermediate and Deracemization by a Chiral Sensitizer. Angew. Chem. Int. Ed. 2020, 59, 21640–21647. (Hot Paper)

3. Pan, J.;† Li, X. Y.;† Lin, F.; Liu, J.; Jiao, N. Chemoselective Nitrosylation of Anilines and Alkynes via Fragmentary or Complete NO Incorporation. Chem. 2018, 4, 1427–1442. (†These authors contributed equally.)

4. Liang, Y.-F.;† Li, X. Y.;† Wang, X. Y.; Zou, M. C.; Tang, C. H.; Liang, Y. J.; Song, S.; Jiao, N. Conversion of Simple Cyclohexanones into Catechols. J. Am. Chem. Soc. 2016, 138, 12271−12277. (†These authors contributed equally.)

5. Li, X. Y.; Li, X. W.; Jiao, N. Rh-Catalyzed Construction of Quinolin-2(1H)-ones via C−H Bond Activation of Simple Anilines with CO and Alkynes. J. Am. Chem. Soc. 2015, 137, 9246−9249.

6. Sun, X.;† Li, X. Y.;† Song, S.; Zhu, Y. C.; Liang, Y. F.; Jiao, N. Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols. J. Am. Chem. Soc. 2015, 137, 6059−6066. (†These authors contributed equally.)

7. Chen, F.;† Huang, X. Q.;† Li, X. Y.;† Shen, T.; Zou, M. C.; Jiao, N. Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions. Angew. Chem. Int. Ed. 2014, 53, 10495–10499. (†These authors contributed equally.)

8. Wen, X. J.;† Li, X. Y.;† Luo, X.; Wang, W. J.; Song, S.; Jiao, N. Intramolecular Csp -H/C-C Bond Amination of Alkyl Azides for the Selective Synthesis of Cyclic Imines and Tertiary Amines. Chem. Sci. 2020, 11, 4482−4487. (†These authors contributed equally.)

9. Li, X. Y.; Pan, J.; Wu, H.; Jiao, N. Rh-catalyzed Aerobic Oxidative Cyclization of Anilines, Alkynes, and CO. Chem. Sci. 2017, 8, 6266−6273.

10. Li, X. Y.; Pan, J.; Song, S.; Jiao, N. Pd-catalyzed Dehydrogenative Annulation Approach for the Efficient Synthesis of Phenanthridinones. Chem. Sci. 2016, 7, 5384−5389 (ISACS19: Challenges in Organic Chemistry).

11. Li, X. Y.; Jandl, C.; Bach, T. Visible-Light-Mediated Enantioselective Photoreactions of 3‑Alkylquinolones with 4‑O‑Tethered Alkenes and Allenes. Org. Lett. 2020, 22, 3618−3622.

12. Li, X. Y.; Jandl, C.; Bach, T. Synthesis of Azocane- and Oxocane-annulated Furans by a [2+2] Photo­cycloaddition-Ring Opening Cascade. Synthesis 2021, 53, 723−730.

13. Li, X. Y.; Jiao, N. Reoxidation of Transition-metal Catalysts with O2. Chin. J. Chem. 2017, 35, 1349–1365.

14. Li, X. Y.;† Jin, X.;† Xu, J. X. Annuloselectivity in Reactions of Diacyl Dichlorides and Imines: Combined Experimental and Theoretical Studies. J. Org. Chem. 2015, 80, 6976−6985. (†These authors contributed equally.)

15.Li, X. Y.; Xu, J. X. DFT and Experimental Exploration of Intramolecular [2+2+2] Cycloaddition of Oxanorbornadienedicarboxylates and Analogues. J. Org. Chem. 2013, 78, 3039−3047.

16. Li, X. Y.; Xu, J. X. Annuloselectivity in Cycloadditions of Ketenes with Imines: A DFT Study. J. Org. Chem. 2013, 78, 347−355.

17. Li, X. Y.; Xu, J. X. Theoretical insights into the [4+2]/retro [4+2] cycloaddition approach to the synthesis of biaryls and polycyclic aromatics. Sci. China Chem. 2013, 56, 633–640.

（最后更新日期：2025.9.28）