【个人简历】

2022.3- 至今       上海大学理学院化学系，教授

2018.6-2022.2   上海大学理学院化学系，副研究员

2009.6-2018.5   中国科学院上海有机化学研究所，金属有机化学国家重点实验室，副研究员

2007.10-2009.5   日本京都大学，博士后，导师：Keiji Maruoka教授

2005.10-2007.9   日本冈山理科大学，博士后，导师：Junzo Otera教授

2000.8-2005.7   中国科学院上海有机化学研究所，有机化学专业，理学博士，导师：侯雪龙 研究员

1996.9-2000.7   江西师范大学，化学教育专业，本科

【研究领域】

手性药物与不对称催化合成

迄今，在Chem. Rev., Nat. Commun., Angew. Chem. Int. Ed., ACS Catalysis等学术刊物发表SCI论文60余篇，论文他引1200次以上，Web of Science统计H指数23，论文多次被Synfacts等国际评论期刊作为亮点介绍。受邀为国际知名学术出版社Elsevier学术专著撰写章节。主持国家自然科学面上项目3项和青年基金项目1项，主持上海市自然科学基金项目1项。2015年获得德国Thieme出版社的Thieme Chemistry Journals Award。担任国家自然科学基金项目通讯评审专家，浙江省自然科学基金项目通讯评审专家，《Chinese Chemical Letters》期刊第六届编委会委员。指导研究生获得化学系陈念贻奖学金

【讲授课程】

研究生：《高等有机化学》

本科生：《有机化学》、《大学化学》（英文）、《药物化学》、《金属有机化学》、《有机化学实验》

【科研项目】

1．国家自然科学基金面上基金 (项目编号：22071143)，“基于π-烯丙基钯1,4/5-两性离子与烯/炔烃的不对称环加成反应研究”，2021-2024，项目负责人

2．国家自然科学基金面上基金 (项目编号：21772215)，“钯催化烯基三元环与单吸电子基活化烯烃的不对称[3+2]环加成反应及应用研究”，2018-2021，项目负责人

3．国家自然科学基金面上基金 (项目编号：21372242)，“通过钯催化不对称Heck反应实现的动力学拆分及应用研究”，2014-2017，项目负责人

4．国家自然科学基金青年基金 (项目编号：21002113)，“钯催化不对称烯丙基取代反应对亲核试剂的去对称化反应研究及其在天然产物合成中的应用”，2011-2013，项目负责人

5．上海市科学技术委员会自然科学基金 (项目编号：10ZR1436800)，“钯催化不对称烯丙基取代反应对于碳亲核试剂的动力学拆分”，项目负责人

6．国家自然科学基金重点项目 (项目编号：21532010)，“基于亲核试剂对π-烯丙基过渡金属络合物反应选择性的反应方法学研究”，2016-2020，主要骨干

【主要学术论文】

1. Yaping Zhang, Wei Zhou, Mingchun Gao, Tianqi Liu, Bingxin Liu, Chang-Hua Ding,^⁎ Bin Xu^⁎  Oxidative cyclization of allyl compounds and isocyanide: a facile entry to polysubstituted 2-cyanopyrroles. Chinese Chem. Lett. 2024, 35, 108836. (IF = 9.1, 中科院一区).

2. Juan Du,∗ Yun-Fan Li, Chang-Hua Ding∗  Recent advances of Pd-π-allyl zwitterions in cycloaddition reactions. Chinese Chem. Lett. 2023, 34, 108401. (IF = 9.1, 中科院一区).

3. Shaohang Lu, Chang-Hua Ding,* and Bin Xu*  Triple-Consecutive Isocyanide Insertions with Aldehydes: Synthesis of 4‑Cyanooxazoles. Org. Lett. 2023, 25, 849−854. (Highlighted by学术网站Org. Chem. Portal; IF = 5.2, 中科院一区).

4. Shuai Huang, Gao-Peng Zhang, Yang-Jie Jiang, Fei-Le Yu, Chang-Hua Ding,* and Xue-Long Hou,* Pd-Catalyzed umpolung asymmetric allylic alkylation of hydrazones to vicinal tertiary and quaternary chiral carbon centers. Chem. Commun. 2022, 58, 3513–3516. (IF = 4.9，中科院二区).

5. Shuai Huang, Fei-Fei Tong, Da-Chang Bai, Gao-Peng Zhang, Yang-Jie Jiang, Bo Zhang, Xuebing Leng, Ying-Long Guo, Xiao-Long Wan, Xingang Zhang,* Chang-Hua Ding,* Xue-Long Hou,* Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand. Nat. Commun. 2021, 12, 6551. (Highlighted by学术网站《纳米人》; IF = 16.6, 中科院一区).

6. Cun Yang, Zhi-Xiong Yang, Chang-Hua Ding,* Bin Xu, Xue-Long Hou,* Development of Dipolarophiles for Catalytic Asymmetric Cycloadditions through Pd-π-allyl zwitterions. Chem. Rec. 2021, 21, 1442–1454. (IF = 6.6, 中科院二区)

7. Weixiang Wang, Tianqi Liu, Chang-Hua Ding,* Bin Xu,* C(sp³)–H Functionalization with Isocyanides. Org. Chem. Front. 2021, 8, 3525-3542. (IF = 5.4, 中科院一区).

8. Juan Du, Yuan-Da Hua, Yang-Jie Jiang, Shuai Huang, Di Chen, Chang-Hua Ding,* Xue-Long Hou,* Palladium-Catalyzed Asymmetric Decarboxylative [4+2] Dipolar Cycloaddition of 4‑Vinyl-1,3-dioxan-2-ones with α,β-Disubstituted Nitroalkenes Enabled by a Benzylic Substituted P,N-Ligand. Org. Lett. 2020, 22, 5375−5379. (Highlighted by学术网站Org. Chem. Portal; IF = 5.2，中科院一区).

9. Wen-Ping Ding, Gao-Peng Zhang, Yang-Jie Jiang, Juan Du, Xiu-Yan Liu, Di Chen, Chang-Hua Ding,* Qing-Hai Deng,* Xue-Long Hou,* Electron-Deficient Alkynes as Dipolarophile in Pd-Catalyzed Enantioselective (3+2) Cycloaddition Reaction with Vinyl Cyclopropanes. Org. Lett. 2019, 21, 6805–6810. (IF = 5.2, 中科院一区).

10. Leiyang Zhao, Bingxin Liu, Qitao Tan, Chang-Hua Ding,* and Bin Xu,* Silver-Assisted Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β‑Carbonyl α‑Iminonitriles. Org. Lett. 2019, 21, 9223−9227.(Highlighted by Synfacts, 2018,14,1163,IF=5.2.中科院一区)

11. Fei-Le Yu, Da-Chang Bai, Xiu-Yan Liu, Yang-Jie Jiang, Chang-Hua Ding,* Xue-Long Hou,* Pd-Catalyzed Allylic Alkylation of gem-Alkyl,Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers. ACS Catalysis, 2018, 8, 3317−3321.(IF = 12.9, 中科院一区).

12. Jian-Qiang Huang, Wei Liu, Bao Hui Zheng, Xiu Yan Liu, Zhen Yang, Chang-Hua Ding,* Hao Li, Qian Peng,* Xue-Long Hou,* Pd-Catalyzed Asymmetric Cyclopropanation Reaction of Acyclic Amides with Allyl and Polyenyl Carbonates. Experimental and Computational Studies for the Origin of Cyclopropane Formation. ACS Catalysis, 2018, 8, 1964-1972.(封面论文，IF=12.9，中科院一区).

13. Wan-Ying Wang, Jing-Yu Wu, Qing-Rong Liu, Xiu-Yan Liu, Chang-Hua Ding,* Xue-Long Hou,* Palladium/N‑Heterocyclic Carbene (NHC)-Catalyzed Asymmetric [3+2] Cycloaddition Reaction of Vinyl Epoxides with Allenic Amides, Org. Lett. 2018, 20, 4773−4776. (Highlighted by Synfacts, 2018, 14, 1163; IF = 5.2, 中科院一区).

14. Juan Du, Yang-Jie Jiang, Jia-Jia Suo, Wen-Qiong Wu, Xiu-Yan Liu, Di Chen, Chang-Hua Ding,* Yin Wei,* Xue-Long Hou,* Trisubstituted alkenes with a single activator as dipolarophiles in a highly diastereo- and enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis. Chem. Commun. 2018, 54, 13143–13146. (IF = 4.9, 中科院二区).

15. Jia-Jia Suo, Juan Du, Qing-Rong Liu, Di Chen, Chang-Hua Ding,* Qian Peng,* Xue-Long Hou,* Highly Diastereo- and Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Epoxides and α,β-Unsaturated Ketones. Org. Lett. 2017, 19, 6658−6661. (Highlighted by Synfacts, 2018, 14, 166; IF = 5.2，中科院一区).

16. Yang-Jie Jiang, Gao-Peng Zhang, Jian-Qiang Huang, Di Chen, Chang-Hua Ding,* Xue-Long Hou,* Palladium-Catalyzed Asymmetric Allylic Alkylation of Alkyl-Substituted Allyl Reagents with Acyclic Amides. Org. Lett. 2017, 19, 5932–5935

.(Highlighted by Synfacts, 2018,14,45;IF=5.2,中科院一区).

17. Chao-Fan Xu, Bao-Hui Zheng, Jia-Jia Suo, Chang-Hua Ding,* Xue-Long Hou,* Highly Diastereo- and Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Aziridines and α, β-Unsaturated Ketones. Angew. Chem. Int. Ed. 2015, 54, 1604-1607. (Highlighted by学术网站Org. Chem. Portal;《有机化学》杂志“亮点介绍”; IF = 16.6, 中科院一区).

18. Qing-Song Zhang, Shi-Li Wan, Di Chen, Chang-Hua Ding,* Xue-Long Hou,* Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for construction of a chiral quaternary carbon center. Chem. Commun. 2015, 51, 12235-12238. (Highlighted by Org. Chem Portal网站;IF=4.9,中科院二区).

19. Bai-Lin Lei, Qing-Song Zhang, Wei-Hua Yu, Qiu-Ping Ding, Chang-Hua Ding,* Xue-Long Hou,* Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I. Org. Lett. 2014, 16, 1944-1947. (IF = 5.2, 中科院一区).

20. Guang-Cun Ge, Xiao-Jun Huang, Chang-Hua Ding,* Shi-Li Wan, Li-Xin Dai, Xue-Long Hou,* A new strategy to construct a C=C-CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums. Chem. Commun. 2014, 50, 3048-3051. (IF = 4.9, 中科院二区).

21. Xiao-Fei Yang, Xiao-Hui Li, Chang-Hua Ding,* Chao-Fan Xu, Li-Xin Dai, Xue-Long Hou,* Pd-catalyzed allylic alkylation of dienyl carbonates with nitromethane with high C-5 regioselectivity. Chem. Commun. 2014, 50, 484-486. (IF = 4.9, 中科院二区)

22. Yang Yu, Xiao-Fei Yang, Chao-Fan Xu, Chang-Hua Ding,* Xue-Long Hou,* Desymmetrization of Bicyclo[3.n.1]-3-one Derivatives by Palladium-Catalyzed Asymmetric Allylic Alkylation. Org. Lett. 2013, 15, 3880-3883. (Highlighted by Synfacts, 2013, 9,1195; IF = 5.2，中科院一区).

23. Chang-Hua Ding,* Xue-Long Hou,* Catalytic Asymmetric Propargylation. Chem. Rev. 2011, 111, 1914-1937. (IF = 62.1, 中科院一区).

【专著章节】

1. Zhi-Chun Zheng, Cun Yang, Xin Kuang, Chang-Hua Ding, Thiophenes and Their Benzo Derivatives: Synthesis. In “Comprehensive Heterocyclic Chemistry IV” vol. 3, pp. 519-612. Oxford: Elsevier, 2022

2. Chang-Hua Ding, Xue-Long Hou, Nucleophiles with Allyl Metal Complexes. In “Additions to and Substitutions at C‐C π‐Bonds” Comprehensive Organic Synthesis 2^nd edition, Vol. 4. pp 648-698 (Vol. Eds: S. Ma and J. Zhang), Elsevier, 2014

3. Chang-Hua Ding, Xue-Long Hou,* Transition Metal-Catalyzed Asymmetric Allylation. Top Organomet Chem 2011, 36, 247-286.