今日化学系列报告第136讲：Biosynthesis of the Loline Alkaloids-上海大学理学院化学系

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今日化学系列报告第136讲：Biosynthesis of the Loline Alkaloids


创建时间： 2015年06月08日 00:00 王越浏览次数：

报告题目：Biosynthesis of the Loline Alkaloids

报告时间：6月10日上午10：00

报告地点：HA102

报告人：Prof. Robert B. Grossman (Department of Chemistry

University of Kentucky)

报告摘要：The loline alkaloids are a group of insecticidal alkaloids produced by endophytic fungi living inside of cool-season grasses. These small secondary metabolites consist of a pyrrolizidine ring bearing an amino group and a strained ether bridge in a very unusual context for a biological product. We have identified and sequenced the gene cluster that encodes the enzymes responsible for synthesizing the loline alkaloids, and, with a combination of various chemical and molecular biological techniques, we have established the biochemical pathway that fungi use to prepare lolines, and we have mostly identified which enzymes are responsible for catalyzing which steps in the biosynthesis. Among our more unusual findings is that a PLP-dependent gamma-lyase, LolC, probably catalyzes the formation of a C–N bond in the first committed step of loline biosynthesis, and that a single non-heme iron-dependent oxidase, LolO, is responsible for introducing both C–O bonds of the ether bridge in a four-electron oxidation.

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